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Neutrophils, interleukin-17A and lung disease
The roles of neutrophils and interleukin-17A in lung disease
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Abstract
Excessive and sustained mobilization of neutrophils is a hallmark of chronic inflammatory lung disorders.
- Interleukin (IL)-17A is identified as a major orchestrator of sustained neutrophil mobilization.
- IL-17A is produced by T-lymphocytes and influences neutrophil activity in the lungs.
- The cytokine acts indirectly by inducing the release of specific cytokines and colony-stimulating factors from resident lung cells.
- Recent studies support the involvement of IL-17A in inflammatory lung disorders, but its causative role remains uncertain.
- IL-17A's position at the interface of acquired and innate immunity suggests it may be an important signal for host defense.
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