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Synthesis of novel pyrazole derivatives and neuroprotective effect investigation.
New Pyrazole Compounds and Their Potential to Protect Nerves
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Abstract
The most potent compound demonstrated an IC50 value of 9.562 μM for suppressing IL-6 expression.
- 27 novel pyrazole derivatives were designed and synthesized for evaluation.
- The anti-inflammatory activity was assessed in lipopolysaccharide-stimulated BV2 microglial cells.
- Key pro-inflammatory cytokines, including tumour necrosis factor-α, interleukin-1β, and interleukin-6, were analyzed via mRNA expression levels.
- One compound showed superior inhibitory potency against IL-6 compared to dexamethasone and Celecoxib.
- No significant cytotoxicity was observed for the most potent compound.
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