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New mRNA vaccines producing strong protection against drug-resistant Enterobacteriaceae bacteria
Updated
Abstract
Essence
Fusion-protein mRNA vaccines targeting PstS and YidR protected mice against multidrug-resistant Enterobacteriaceae challenge.
Evidence
This preclinical vaccine study tested antigen expression in vitro and mouse protection against Klebsiella pneumoniae, enterohemorrhagic Escherichia coli, Salmonella enterica, and Shigella flexneri.
Caveat
Protection was shown in vitro and in mice, so human immunogenicity, dosing, durability, and safety remain untested.
Simplified
mRNA Technology