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Next-generation mRNA vaccines eliciting robust protection against multidrug-resistant Enterobacteriaceae
New mRNA vaccines producing strong protection against drug-resistant Enterobacteriaceae bacteria
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Abstract
The K. pneumoniae-based mRNA vaccine (KV3) significantly reduced bacterial loads and organ damage in mice.
- Two novel target antigens were identified for mRNA vaccine development: phosphate-specific transport protein (PstS) and DUF3748 domain-containing protein (YidR).
- The fusion proteins derived from these antigens showed high expression and secretion in laboratory settings.
- The vaccine demonstrated strong protective efficacy against Klebsiella pneumoniae and enterohemorrhagic Escherichia coli in mouse models.
- Notably, KV3 provided cross-protection against four Enterobacteriaceae species, including Salmonella enterica and Shigella flexneri.
- These findings highlight the potential of mRNA vaccines to combat multidrug-resistant bacterial infections.
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