Next-Generation Nanoparticle-Enabled mRNA Vaccines in the Treatment of COVID-19

Sep 8, 2025Critical reviews in therapeutic drug carrier systems

mRNA Vaccines Using Advanced Nanoparticles for Treating COVID-19

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mRNA Technology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Two mRNA vaccines, BNT162b2 and mRNA-1273, have received emergency usage authorization from the USFDA for preventing COVID-19 infection.

mRNA vaccines utilize nanoparticles to enhance stability and delivery, improving their effectiveness compared to traditional vaccines.
Lipid nanoparticles serve as the primary delivery platform for both authorized mRNA vaccines.
Ongoing pre-clinical and clinical developments are focused on mRNA vaccine candidates and their efficacy against various coronavirus variants.
Recent advancements in delivery strategies include lipid nanoparticles, polymeric nanoparticles, and exosomes for immunization.
Key challenges in mRNA nanoparticle technology have been identified, alongside proposed strategies to address these issues.

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The emergence of messenger ribonucleic acid (mRNA) vaccines as an alternative platform to traditional vaccines has been accompanied by advances in nanobiotechnology, which have improved the stability and delivery of these vaccines through novel nanoparticles (NPs). Specifically, the development of NPs for mRNA delivery has facilitated the loading, protection and release of mRNA in the biological microenvironment, leading to the stimulation of mRNA translation for effective intervention strategies. Intriguingly, two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), have been permitted for emergency usage authorization to prevent COVID-19 infection by USFDA. Both mRNA vaccines utilized lipidic NPs (LNPs) as a delivery platform and demonstrated superior efficacy and safety profiles compared to traditional vaccines. This review article gives insight into ongoing pre-clinical and clinical developments of mRNA vaccine candidates, their efficacy against coronavirus variants, and analysis of NP-based approaches to recognize their potential for forthcoming growth. This review article highlights recent advances in delivery strategies, including LNPs, polymeric NPs, and exosomes, for effective immunization against COVID-19. The key challenges associated with mRNA NPs have been identified, and potential strategies to overcome these difficulties have been proposed. Production of nanomaterials for specific mRNA applications can offer new insights into next-generation nanomaterials, revolutionizing mRNA technology.

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Next-Generation Nanoparticle-Enabled mRNA Vaccines in the Treatment of COVID-19

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