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Abstract
Surface chemistry influences the behavior of lipid-based nanocarriers, particularly through PEGylation.
- PEGylation creates a steric barrier that enhances the circulation time of lipid nanoparticles in the body.
- The use of PEG can lead to the development of anti-PEG antibodies, resulting in accelerated blood clearance upon repeat dosing.
- Hypersensitivity reactions, such as complement activation-related pseudoallergy, have been associated with PEGylated nanocarriers.
- While PEGylation offers stealth properties, it can also limit the effectiveness of cargo delivery by reducing interactions with cells.
- Alternative amide-based polymers may exhibit similar stealth characteristics while potentially reducing immune responses and improving delivery efficiency.
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