NF‐YCs modulate histone variant H2A.Z deposition to regulate photomorphogenic growth in Arabidopsis

Light irradiation induces H2A.Z deposition at target loci in Arabidopsis thaliana, inhibiting hypocotyl growth.

• H2A.Z, an evolutionarily conserved histone variant, plays a role in regulating gene expression during photomorphogenesis.
• The NUCLEAR FACTOR-Y, subunit C (NF-YC) proteins are involved in the light-induced deposition of H2A.Z.
• NF-YCs interact with ACTIN-RELATED PROTEIN6 (ARP6), a key component necessary for H2A.Z deposition, in a light-dependent manner.
• Both NF-YCs and ARP6 work together as negative regulators of hypocotyl growth by facilitating H2A.Z deposition at target genes.
• These findings highlight the role of H2A.Z in controlling plant growth in response to light changes.

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