β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

Nicotinamide mononucleotide (NMN) treatment blocked UVB-induced photodamage in mice.

• NMN treatment maintained normal skin structure, collagen fiber amounts, and epidermis and dermis thickness after UVB exposure.
• The treatment reduced the production of mast cells and preserved organized skin structure.
• NMN intraperitoneal injection protected mouse liver morphology from UVB damage.
• The treatment increased antioxidant ability by enhancing antioxidant enzyme activity and reducing hydrogen peroxide production.
• NMN regulated inflammatory responses by decreasing pro-inflammatory cytokines and increasing anti-inflammatory cytokines.
• Activation of the AMP-activated protein kinase (AMPK) signaling pathway by NMN reduced oxidative stress and modulated gene expression related to inflammation.

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