Nicotinamide mononucleotide and glucose together reduce iron-related energy problems in mice under low oxygen pressure

A combined regimen of nicotinamide mononucleotide (NMN) and glucose significantly mitigates tissue injury and body weight loss in mice exposed to hypobaric hypoxia.

• Hypobaric hypoxia (HH) is associated with iron overload and oxidative stress, which are identified as key pathological factors.
• The supplementation of NMN and glucose counteracts metabolic disruptions in various tissues affected by HH.
• HH triggers transferrin-inspired iron delivery that contributes to oxidative stress and depletion of antioxidants such as glutathione.
• While no significant changes were noted in ferroptotic protein markers, NMN and glucose may reverse metabolic alterations linked to ferroptosis.
• The findings suggest that NMN combined with glucose alleviates mitochondrial dysfunction in the context of HH-induced multi-organ injury.

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