Nicotinamide mononucleotide helps improve polycystic ovary syndrome by boosting energy use through activating a protein that changes lactate dehydrogenase

Polycystic ovary syndrome (PCOS) is linked to impaired glycolytic activity in granulosa cells.

• Impaired glycolytic activity in granulosa cells may contribute to the pathology of PCOS.
• Lactate dehydrogenase A (LDHA), a key enzyme in glycolysis, is influenced by acetylation.
• The regulatory mechanism of LDHA in the context of PCOS is not fully understood.
• Nicotinamide mononucleotide (NMN) may promote LDHA deacetylation.
• Enhancing LDHA function through NMN could potentially alleviate symptoms of PCOS.

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