Full text is available at the source.
Abstract
Doxorubicin treatment is associated with testicular toxicity in male rats.
- Chemotherapy with doxorubicin may lead to increased testicular apoptosis.
- Inflammatory changes are observed in the testes of rats treated with doxorubicin.
- Oxidative stress is a potential consequence of doxorubicin exposure in testicular tissue.
- Nicotinamide mononucleotide (NMN) is being investigated for its ability to protect against these effects.
- Improved mitochondrial function is a proposed mechanism for NMN's protective role.
Simplified