The effects of exposure to night shift work on liver function: A cross-sectional study with emphasis of alkaline phosphatase enzyme

Nov 8, 2019Chronobiology international

How Night Shift Work May Affect Liver Health, Focusing on an Important Liver Enzyme

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Abstract

Workers on 12-hr rotating night shifts had significantly higher levels of alkaline phosphatase (ALP) compared to those on 12-hr fixed-day shifts.

The average ALP level for the rotating night shift group was 196.2 ± 52.1, while it was 191.5 ± 53.4 for the fixed-day group.
Logistic regression analysis indicated that the odds of having high ALP levels were 1.26 times greater for the rotating night shift group compared to the fixed-day group.
The same odds ratio of 1.26 was observed for severe levels of ALP in the rotating night shift group versus the fixed-day group.
Age, body mass index, fasting blood sugar, and total cholesterol were considered significant variables in the analysis.

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: Previous studies have demonstrated that shift work can be significantly associated with adverse effects on liver function. However, the association between shift work and alkaline phosphatase (ALP) enzyme as a well-known biomarker of liver disease has been undefined.: This cross-sectional study was conducted on a total number of 6,475 eligible oil refinery workers. According to shift work schedules, the participants divided to the following groups: 12-hr rotating night (= 2,630) and 12-hr fixed day (= 3845). The Spearman's correlation and logistic regression were applied to assess the association between shift work and ALP.: We found significantly higher levels of ALP in 12-hr rotating night compared to 12-hr fixed-day shift work groups (196.2 ± 52.1 versus 191.5 ± 53.4). According to quartile (Q) logistic regression adjusted by significant variables between study group (age, body mass index, fasting blood sugar, and total cholesterol), the odds ratio and 95% confidence interval of high (Q2-<Q3 versus <Q1) and severe (≥Q3 versus <Q1) levels of ALP in 12-hr rotating night group in comparison to 12-hr fixed-day group were estimated as 1.26 (1.08-1.45) and 1.26 (1.09-1.45), respectively.: This study indicated that 12-hr rotating night shift work may be associated with higher levels of ALP. More studies are needed to confirm our findings. Background Methods Results Conclusions n n

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The effects of exposure to night shift work on liver function: A cross-sectional study with emphasis of alkaline phosphatase enzyme

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