Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review

Dec 29, 2022Steroids

Building nitrogen-containing six-membered rings on steroid structures: A review

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Abstract

Steroidal heterocyclic compounds exhibit diverse chemical reactivity and various biological activities.

Recent advancements in the chemistry of steroid skeletons were reported, focusing on reactions at the A, B, and D ring systems.
Modern synthetic methods for creating nitrogen-containing six-membered heterocyclic derivatives from multiple steroid types were discussed.
Certain steroidal compounds have demonstrated therapeutic potential as cytotoxic agents against different cell lines.
These compounds may exhibit antiproliferative, anti-inflammatory, and antioxidant activities.
Steroidal N-containing heterocyclic derivatives could serve as prospective candidates for new medications.

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Steroidal heterocyclic compounds constitute interesting and promising scaffolds for drug discovery as they have displayed diverse chemical reactivity and several types of biological activities. This study is a concise report on the most recent advancements in the chemistry of the steroid skeleton, including reactions at the A, B, and D ring systems. The modern synthetic methods for the steroidal nitrogen-containing six-membered heterocyclic derivatives from 3-keto-, 6-keto-, 17-keto-, and 20-keto-steroids, as well as 2-Aldo-, 4-Aldo-, 6-Aldo-, and 16-Aldo-steroids, are discussed. However, some other methods for the synthesis of steroidal N-containing 6-membered heterocyclic derivatives are also included. These compounds have shown therapeutic potential as cytotoxic agents against various cell lines and have also shown antiproliferative, anti-inflammatory, and antioxidant activities. Therefore, they could be used as prospective candidates for the development of various medications. This paper not only describes synthetic details involved in creating N-containing 6-membered heterocyclic steroid derivatives, but also provides a brief overview of the medicinal applications of these compounds. This information will be highly useful for the medicinal chemists conducting research in this field.

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Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review

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