Steroids

Building nitrogen-containing six-membered rings on steroid structures: A review

Updated

Abstract

Steroidal heterocyclic compounds exhibit diverse chemical reactivity and various biological activities.

  • Recent advancements in the chemistry of steroid skeletons were reported, focusing on reactions at the A, B, and D ring systems.
  • Modern synthetic methods for creating nitrogen-containing six-membered heterocyclic derivatives from multiple steroid types were discussed.
  • Certain steroidal compounds have demonstrated therapeutic potential as cytotoxic agents against different cell lines.
  • These compounds may exhibit antiproliferative, anti-inflammatory, and antioxidant activities.
  • Steroidal N-containing heterocyclic derivatives could serve as prospective candidates for new medications.

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Competing interests

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PubMed

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