Brain research bulletinApr 4, 2026

How Non-Coding RNA May Influence Cell Cleanup Processes in Alzheimer's Disease

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 5, 2026

Abstract

Dysfunctional autophagy is implicated in the pathogenesis of Alzheimer's disease.

Alzheimer's disease is a major cause of dementia, affecting patients and healthcare systems globally.
Autophagy is essential for removing damaged cellular components and maintaining metabolic balance.
Non-coding RNAs, including microRNAs, long ncRNAs, and circular RNAs, regulate autophagy and influence Alzheimer's disease progression.
Targeting the interaction between non-coding RNAs and autophagy may offer new therapeutic strategies for Alzheimer's disease.

Simplified

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and one of the leading causes of dementia, imposing a profound burden on patients, families, and healthcare systems worldwide. Autophagy, an evolutionarily conserved lysosomal degradation pathway critical for maintaining cellular homeostasis, removes damaged organelles and misfolded proteins, thereby preserving metabolic balance and enabling intracellular biomolecule recycling. Growing evidence indicates that dysfunctional autophagy contributes to AD pathogenesis. Concurrently, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as pivotal regulators of AD pathology, particularly through mechanisms involving autophagy. These ncRNAs not only play a role in disease progression but also represent promising molecular targets for therapeutic intervention via autophagy modulation. This review systematically explores the regulatory networks through which ncRNAs influence autophagy in AD, with the goal of identifying potential therapeutic targets and offering a conceptual framework to guide clinical translation.

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Declaration of Competing Interest The authors declare there are no conflicts of interest.

PubMed

How Non-Coding RNA May Influence Cell Cleanup Processes in Alzheimer's Disease

Abstract

Full Text

Funding

Competing interests

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