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Abstract
Obesity is associated with impaired adipocyte metabolism driven in part by mitochondrial dysfunction.
- Mitochondrial dysfunction may contribute to metabolic issues in obesity.
- STK3 and STK4 are proteins that promote the removal of damaged mitochondria (mitophagy) in fat cells.
- Reduced mitochondrial mass in adipose tissue could be a consequence of increased mitophagy.
- Inhibiting STK3/4 may offer a new approach to treat obesity and related metabolic disorders.
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