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Abstract
Compound 25 (UCM-17017) decreases β-galactosidase activity in senescent human fibroblasts.
- A novel bioactive compound was identified through screening a library of small molecules targeting cellular senescence.
- UCM-17017 selectively reduces the viability of senescent lung cancer cells compared to proliferative cells.
- The compound shows a favorable pharmacokinetic profile in living organisms.
- It induces a beneficial effect in a mouse model of pulmonary fibrosis, a disease associated with cellular senescence.
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