Molecular and cellular endocrinologyNov 26, 2008

Linking DNA damage inside the cell nucleus to lifespan

Updated Feb 11, 2026

Abstract

Progeroid syndromes in mouse models show that defects in DNA damage response may lead to rapid aging and premature death.

Progressive genome instability is linked to the aging process.
Inherited defects in nucleotide excision repair are associated with progeroid syndromes.
Mouse models exhibit quick onset of aging symptoms.
Alterations in genome maintenance pathways could influence age-related diseases.
These pathways are also related to longevity.

Simplified

A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the aging process. Here, we review a number of mouse models for progeroid syndromes that are caused by inherited defects in nucleotide excision repair and are characterized by rapid onset of aging symptoms and premature death. We argue that alterations in genome maintenance pathways impact complex physiological processes that may affect the onset of clinically defined age-related pathologies, including cancer as well as pathways that are normally associated with longevity.

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Abstract

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