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Nucleic Acid-Based Therapeutics for Pulmonary Diseases
Gene-Based Treatments for Lung Diseases
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Abstract
Nucleic acid-based therapeutics show potential for treating pulmonary diseases, which are often fatal and widely prevalent.
- Nucleic acids are susceptible to degradation, complicating effective delivery to the lungs.
- Different strategies, such as chemically synthesized nucleic acids and vector encapsulation, have been employed to enhance delivery efficiency.
- Concerns regarding off-target effects and immune stimulation currently limit the clinical application of nucleic acid drugs.
- Effective clinical use of nucleic acid therapeutics may depend on the development of safer carriers and delivery methods.
- The review discusses the mechanisms of nucleic acid drugs, novel delivery systems, and formulations for lung administration.
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