Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast

Npr1, a nucleophagy receptor, is identified in the fission yeast Schizosaccharomyces pombe.

• Npr1 is an Atg8-binding protein located on the outer nuclear membrane.
• It works alongside another receptor, Epr1, to facilitate nucleophagy during nitrogen starvation.
• Cells lacking both Npr1 and Epr1 display abnormal nuclear shape and lower survival rates.
• During nucleophagy, the nuclear envelope forms protrusions where Atg8 interacts with Npr1 and/or Epr1.
• These protrusions detach to create autophagosomes containing nuclear components.
• Enhancing chromatin attachment to the inner nuclear membrane prevents protrusion detachment, stopping nucleophagy.

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