The European journal of neuroscience

Skipping nursing shifts daily biological clocks in the brain's timekeeping center of rat pups

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Periodic maternal deprivation during the first week of life completely phase-reversed circadian rhythms in neonatal rats.

  • The absence of nursing mothers altered the expression rhythms of the clock genes rPer1 and rPer2 in the pups' brain regions associated with circadian regulation.
  • Spontaneous locomotor activity in the pups was also affected after weaning at postnatal day 21.
  • Stress-related gene expressions, including corticotropine-releasing hormone, arginine vasopressin, and glucocorticoid receptor, were modified in the mother-deprived pups.
  • These changes occurred specifically in certain brain areas of the pups by postnatal day 6.
  • The findings suggest that maternal absence may reset the neonatal circadian clock and influence stress responses.

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