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Nutrient-Adjusted High-Fat Diet is Associated with Absence of Periepididymal Adipose Tissue Inflammation: Is there a Link with Adequate Micronutrient Levels?
High-fat diets with enough micronutrients are linked to no inflammation in fat around the testes
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Abstract
Isocaloric intake of an adjusted high-fat diet increased periepididymal adiposity to 2.94 ± 0.77 g/100 g body weight compared to 1.99 ± 0.26 g/100 g body weight in control rats.
- The high-fat diet promoted increased retroperitoneal adiposity (HFD = 3.11 ± 0.81 vs. CON = 2.08 ± 0.39 g/100 g body weight, p = 0.01).
- Total body lipid content was higher in rats on the high-fat diet (HFD = 105.3 ± 20.8 vs. CON = 80.5 ± 7.6 g carcass, p = 0.03).
- Rats on the high-fat diet developed glucose intolerance (p = 0.01) and dyslipidemia (p = 0.02) compared to controls.
- C-reactive protein levels were elevated in high-fat diet rats (HFD = 1002 ± 168 vs. CON = 611 ± 260 ng/mL, p = 0.01).
- The high-fat diet did not alter adipokine gene expression or inflammatory signaling proteins but reduced AKT phosphorylation after insulin stimulation (p = 0.01).
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