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Abstract
Age-related dysregulation of nutrient-sensing pathways is associated with metabolic imbalance and stem cell exhaustion.
- Nutrient-sensing pathways, including mTOR and AMPK, play crucial roles in regulating adult stem cell fate.
- These pathways modulate cellular metabolism and influence transitions between quiescence, activation, and differentiation in stem cells.
- Dysregulation of this network with age may lead to tissue degeneration.
- Interventions such as mTOR inhibitors and AMPK activators could restore metabolic balance in adult stem cells.
- Dietary strategies and NAD+ precursors are also proposed to rejuvenate stem cell function.
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