Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide

Aug 6, 2010Journal of neuro-oncology

Link between DNA repair enzyme levels and survival in older glioblastoma patients treated with radiation and chemotherapy

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Abstract

Median overall survival (OS) was 15.3 months for patients with methylated MGMT promoters, compared to 10.2 months for those with unmethylated promoters.

  • Epigenetic silencing of the MGMT gene through promoter methylation is linked to improved overall survival (OS) and progression-free survival (PFS) in elderly glioblastoma multiforme (GBM) patients.
  • In a study of 83 patients aged 70 and older, 50.6% had methylated MGMT promoters.
  • Median PFS was 10.5 months for patients with methylated tumors, while it was 5.5 months for those with unmethylated tumors.
  • MGMT methylation status was identified as the strongest independent prognostic factor for OS and PFS.
  • Statistical analyses indicated significant differences in survival outcomes based on MGMT methylation status.

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