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Influence and Predicting Variables of Obstructive Sleep Apnea on Cardiac Function and Remodeling in Patients without Congestive Heart Failure
How Obstructive Sleep Apnea May Affect Heart Function and Shape in Patients Without Heart Failure
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Abstract
Patients with moderate to severe obstructive sleep apnea syndrome (OSAS) show significant cardiac dysfunction as measured by echocardiography.
- Body mass index, neck circumference, Epworth Sleepiness Scale, desaturation index, arousal index, and snoring index were significantly higher in patients with moderate to severe OSAS.
- Echocardiographic measures indicated that left atrial size, mitral A-wave velocity, and left ventricular end-diastolic volume were larger in patients with moderate to severe OSAS, while the E/A ratio was lower.
- A higher apnea-hypopnea index (AHI) during REM sleep was significantly correlated with increased aortic root size, lower E/A ratio, and larger left ventricular volume and stroke volume.
- An AHI in REM sleep of ≥ 32.3/h was associated with the development of left ventricular diastolic dysfunction, with an area under the curve of 0.647 for predicting this condition.
- After adjusting for factors like age and body mass index, AHI in REM sleep ≥ 32.3/h remained the only independent predictor of diastolic dysfunction.
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