Circulation research

Obstructive Sleep Apnea and Its Links to Obesity, High Blood Pressure, and Diabetes

Updated

Abstract

Obstructive sleep apnea (OSA) is a strong risk factor for hypertension and diabetes.

  • OSA is characterized by recurrent upper airway obstruction during sleep, leading to intermittent low oxygen levels and increased sympathetic activity.
  • There is a robust association between OSA and cardiometabolic diseases, particularly in individuals who are obese.
  • Clinical studies suggest that OSA may play a causal role in hypertension and glucose metabolism impairments, independent of excess weight.
  • Women are frequently underdiagnosed and undertreated for OSA, potentially increasing their risk for cardiometabolic issues.
  • Treatment of OSA with continuous positive airway pressure has been shown to reduce blood pressure in those with hypertension, though its effects on blood sugar control are less clear.
  • Variability in treatment responses may be influenced by differences in OSA presentation and adherence to therapy among diverse populations.

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Full Text

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Funding

Competing interests

V.K. Somers has served as a consultant for Jazz Pharmaceuticals, Lilly, ApniMed, Axsome, iRhythm, Zoll, and Mineralys. The other authors report no conflicts.
PubMed

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