OLFM4, LCN2, and FAM3B as Possible Indicators of Gut-Brain Problems in People with Both Inflammatory Bowel Disease and Depression

Common biomarkers for inflammatory bowel disease (IBD) and major depressive disorder (MDD) remain elusive.

• There are bidirectional pathogenic interactions between IBD and MDD through the gut-immune-brain axis.
• Core hub genes may play a critical role in the comorbidity of IBD and MDD.
• Conserved signaling pathways are likely involved in the interactions between IBD and MDD.

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