How Omega-3 Fatty Acids May Influence Harmful Sugar-Built Molecules in Aging: Key Processes and Health Implications

Aging is associated with the accumulation of advanced glycation end products (AGEs), which can cause tissue damage.

• AGRs are formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids.
• They contribute to tissue damage by causing irreversible protein cross-linking.
• AGEs also trigger inflammatory signaling through a specific receptor known as RAGE.
• Elderly individuals may be more affected due to factors like oxidative stress and impaired clearance of AGEs.
• Omega-3 polyunsaturated fatty acids, such as EPA and DHA, could potentially influence these damaging pathways.

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