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Beneficial effect of omega-3 fatty acids supplementation on leaky gut, inflammation and oxidative stress in propionic acid-induced autism in aged rats
Omega-3 supplements may reduce gut leaks, inflammation, and oxidative stress in aged rats with autism caused by propionic acid
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Abstract
Twenty-four aged male rats were used to assess the effects of omega-3 fatty acids on neurotoxicity induced by propionic acid.
- Propionic acid exposure led to significant increases in tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), indicating systemic inflammation.
- A reduction in tight-junction protein 1 (TJP1) expression confirmed gut barrier disruption in the presence of propionic acid.
- Supplementation with omega-3 fatty acids selectively lowered IL-6 levels but did not reverse the increase in TNF-α or oxidative stress caused by propionic acid.
- Increased expression of CLDN2 was observed in the PPA + omega-3 group, suggesting a partial and compensatory response of the gut barrier.
- Trends towards increased levels of dopamine, serotonin, and short-chain fatty acids (SCFAs) were noted with omega-3 supplementation, but these were not statistically significant.
- Histological analysis revealed partial preservation of neuronal and intestinal structure in the PPA + omega-3 group compared to propionic acid alone.
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