Optical and SPION-Enhanced MR Imaging Shows that trans-Stilbene Inhibitors of NF-κB Concomitantly Lower Alzheimer's Disease Plaque Formation and Microglial Activation in AβPP/PS-1 Transgenic Mouse Brain

Supplementation with resveratrol and LD55 reduced Aβ plaque density by 2.3-fold and 3.1-fold, respectively, in the hippocampus of transgenic mice.

• Aβ plaque density was lowered in the cortex, caudoputamen, and hippocampus by 1.4 to 2-fold following treatment with either compound.
• Resveratrol and LD55 also decreased average microglial activation by 4.2-fold and 3.5-fold, respectively.
• The reduction in Aβ plaques and neuroinflammation occurred despite LD55 lacking hydroxyl groups, suggesting that antioxidant properties may not be critical for plaque reduction.

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