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Abstract
Chronic inflammatory conditions in the oral cavity may contribute to the development of neurodegenerative diseases.
- Disruption of immune balance in oral tissues has been linked to neurodegenerative diseases like Alzheimer's, Parkinson's, and multiple sclerosis.
- Specific periodontopathogens and oral dysbiosis are associated with systemic immune activation and dysfunction in the blood-brain barrier.
- Microbial components may spread through the bloodstream, stimulating systemic immune responses that impact neurological health.
- Neural signaling pathways, including trigeminal and vagal nerves, could mediate connections between oral health and brain function.
- Clinical and experimental studies suggest a correlation between oral inflammation and cognitive impairment, as well as brain structure changes.
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