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Relationship Between Oral Semaglutide Tablet Erosion and Pharmacokinetics: A Pharmacoscintigraphic Study
How Oral Semaglutide Tablet Dissolving Affects Drug Absorption in the Body
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Abstract
occurred in the stomach regardless of water volume administered.
- Mean time to complete tablet erosion was 85 minutes with 50 mL water and 57 minutes with 240 mL water.
- Semaglutide plasma exposure, measured by the area under the concentration-time curve, was approximately 70% higher with 50 mL water compared to 240 mL water.
- The maximum concentration of semaglutide was also higher with 50 mL water, reaching statistical significance.
- The median time to maximum semaglutide concentration was consistent at 1.5 hours, regardless of water volume.
- Longer times to complete tablet erosion and gastric emptying were significantly correlated with higher plasma semaglutide levels.
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Key numbers
1.51
Mean Time to Complete Erosion Increase
Mean time to was 85 minutes with 50 mL vs. 57 minutes with 240 mL.
70%
Higher Semaglutide Exposure
and maximum concentration were approximately 70% higher with 50 mL vs. 240 mL water.
24 of 26
Subjects Completed Trial
Out of 26 subjects exposed to trial product, 24 completed the trial.