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Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats
Orexin-A neurons, but not melanin-concentrating hormone neurons, may control short-term food intake in rats
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Abstract
Administration of 2-deoxy-D-glucose (400 mg/kg) and insulin (5 U/kg) stimulated food intake and induced c-Fos expression in orexin-A neurons.
- Orexin-A neurons in the hypothalamus are activated during conditions of reduced glucose availability.
- Melanin-concentrating hormone neurons did not show increased activity in response to the same conditions.
- The findings suggest distinct roles for orexin-A and melanin-concentrating hormone neurons in regulating food intake.
- Different input signals may influence the activity of these two types of neurons.
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