Recent trends in orexin research—2010 to 2015

Jun 6, 2015Bioorganic & medicinal chemistry letters

Recent Developments in Research on Orexin (2010–2015)

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Abstract

Specific neurons in the lateral hypothalamus produce the orexin neuropeptides (orexin-A and orexin-B).

  • Orexin peptides are transported to brain areas that regulate sleep-wake cycles, food intake, and emotional states.
  • The orexin system involves two neuropeptides and two G-protein-coupled receptors associated with reward and addictive behaviors.
  • Recent research highlights ongoing developments in understanding the functions and implications of the orexin system.

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