Recent Developments in Research on Orexin (2010–2015)

Specific neurons in the lateral hypothalamus produce the orexin neuropeptides (orexin-A and orexin-B).

• Orexin peptides are transported to brain areas that regulate sleep-wake cycles, food intake, and emotional states.
• The orexin system involves two neuropeptides and two G-protein-coupled receptors associated with reward and addictive behaviors.
• Recent research highlights ongoing developments in understanding the functions and implications of the orexin system.

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