OsHLP1 is a receptor that helps rice plants recycle parts of their cell's protein-making system

The HVA22 family protein OsHLP1 is identified as a potential ER-phagy receptor in rice.

• OsHLP1 interacts with the protein OsATG8b, facilitating the recruitment of ER subdomains during stress.
• The cargo protein OsNTL6, which negatively regulates immune responses, is delivered to autophagosomes by OsHLP1.
• Infection with the fungus Magnaporthe oryzae activates significant disease resistance in rice through the action of OsHLP1.
• AtHVA22J, an ortholog of OsHLP1 found in Arabidopsis thaliana, also induces ER-phagy in plants.
• This study highlights the potential role of a conserved protein family in mediating ER-phagy and immune responses in higher plants.

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