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Enhanced osteoarthritis treatment using an injectable pH-responsive and cartilage-targeted liposome-anchored kartogenin-incorporated methacrylated gelatin hydrogel microspheres
Improved osteoarthritis treatment using injectable pH-sensitive gel spheres that deliver cartilage-targeting kartogenin
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Abstract
Hydrogel microspheres designed for cartilage repair in osteoarthritis exhibited significant cartilage-targeting ability and pH responsiveness.
- A novel nanomaterial was synthesized using liposomes that were functionalized with cartilage-targeting peptides.
- Hydrogel microspheres containing the nanomaterial effectively promoted chondrogenesis and showed anti-inflammatory effects in vitro.
- Transcriptomic analysis indicated that chondrogenesis was primarily induced through collagen trimer formation and extracellular matrix biosynthesis.
- In vivo experiments in a mouse model demonstrated the sustained release of the hydrogel microspheres and their ability to significantly inhibit cartilage degeneration.
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