Understanding and Managing the Combined Loss of Bone and Muscle

Osteosarcopenia, a condition characterized by loss of skeletal muscle and bone mass, is associated with a higher risk of adverse outcomes, including falls and mortality.

• Sarcopenia and osteoporosis often co-occur in older adults, leading to osteosarcopenia.
• Loss of muscle and bone mass is influenced by risk factors related to aging.
• Key biological components involved in osteosarcopenia include mitochondria, the nucleus, and nutrient metabolism.
• Osteosarcopenia is linked to increased risks of fractures, depression, frailty, and mortality.
• Diagnosis requires imaging techniques for bone mineral density and muscle mass, along with assessments of physical performance.
• Management involves a multimodal approach, including exercise, nutrition, and potential pharmacotherapy.

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