Endocrinology

Differences in the function and control of an enzyme involved in hormone production in sheep's pineal and pituitary glands

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

AANAT mRNA expression in the sheep pituitary gland is approximately 1/15th that of the pineal gland in the pars tuberalis.

  • AANAT messenger RNA and functional enzyme are present in the pars tuberalis and pars distalis of the sheep pituitary gland.
  • Expression levels of AANAT mRNA in the pars tuberalis and pars distalis are significantly lower compared to the pineal gland.
  • AANAT mRNA in the pars tuberalis is found in the same cells as the Mel1a receptor.
  • No evidence suggests that cells in the pars tuberalis or pars distalis can synthesize melatonin.
  • cAMP regulation of AANAT mRNA levels differs between the pars tuberalis and the pineal gland.
  • Forskolin represses AANAT mRNA expression in the pars tuberalis but not in the pineal gland.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Mar '04
Melatonin rhythms in sheep are not linked to key enzyme and clock gene activity in the pineal gland
cited by 36 papers
research support, non-u.s. gov't
Oct '02
Melatonin-Making Enzymes in Rhesus Monkeys with Focus on the Key Enzyme AANAT
cited by 81 papers
comparative study
Sep '10
Melatonin production in the pineal gland changes in mice lacking Period1
top 20% journal
cited by 37 papers
research support, non-u.s. gov't
Jul '11
Brain control of night-time production of melatonin and related enzyme in the carp pineal gland (lab study)
cited by 19 papers
research support, non-u.s. gov't
Jun '14
Daily changes of the CRX protein in the rat pineal gland and its role in controlling the enzyme AANAT
top 10% journal
cited by 29 papers
research support, non-u.s. gov't
Sep '12
Inflammation may affect a key gene controlling sleep hormone production in chickens
cited by 22 papers
research support, non-u.s. gov't
Apr '11
Changing protein groups help control melatonin production in the human pineal gland
cited by 45 papers
journal article
Sep '04
Activation of a key melatonin-making enzyme by phorbol esters in cow pineal cells suggests a new regulation pathway
top 20% journal
cited by 6 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
yesterday7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
1 week ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
2 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
3 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
4 weeks ago7 studies
issue #38
Emergency doctors had 67% higher odds of chronic pain when working evening shifts vs. morning shifts
6 weeks ago7 studies
issue #36
Night owls show 77% higher risk of job burnout among firefighters
8 weeks ago7 studies
issue #35
Bacteria exposure resets your internal clock independently of immune responses
9 weeks ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
10 weeks ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
11 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief