Association between oxidative balance score and risk of gout: The NHANES cross‐sectional study, 2007–2018

Jul 10, 2024International journal of rheumatic diseases

Balance of Body Oxidation and Its Link to Gout Risk: A Study from 2007-2018

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Abstract

The highest quartile of the Oxidative Balance Score (OBS) is associated with a 0.72 odds ratio for gout compared to the lowest quartile.

A total of 10,492 participants were analyzed in this cross-sectional study.
The OBS is calculated using 16 dietary and four lifestyle factors to evaluate oxidative stress.
Higher OBS levels may correlate with a lower prevalence of gout.
A negative linear relationship between OBS and gout was observed, although not statistically significant.
Diabetes may influence the observed relationship between OBS and gout risk.

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BACKGROUND: The Oxidative Balance Score (OBS) is a systematic tool to assess the effects of diet and lifestyle in relation to oxidative stress. The association between OBS and gout has not been reported previously. We conducted a cross-sectional study to investigate the complex association between OBS and gout in US adults.

METHODS: In all, 10 492 participants were included in this study. The exposure variable was OBS, which was scored by 16 dietary and four lifestyle factors. Multivariate logistic regression, subgroup analysis, and restricted cubic spline (RCS) regression were used to analyze the association between OBS and gout.

RESULTS: Compared with the lowest OBS quartile group (Q1), the multivariate corrected odds ratio (OR) (95% confidence interval [C]) for the highest quartile of OBS (Q4) was 0.72 (0.52-1.00) (p = .13 for trend); furthermore, the RCS showed a negative linear relationship between OBS and gout (p-nonlinear = .606).

CONCLUSION: In conclusion, the risk of gout is higher with high OBS. The prevalence of gout decreased with higher OBS. Diabetes may alter this negative correlation.

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Association between oxidative balance score and risk of gout: The NHANES cross‐sectional study, 2007–2018

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