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Diversity of oxidative stress and senescence phenotypes induced by chemotherapeutic agents in HUVECs
Different types of cell aging and damage caused by chemotherapy drugs in human blood vessel cells
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Abstract
Etoposide induced senescence in 80% of human umbilical vein endothelial cells, while methotrexate induced senescence in 40%.
- All tested chemotherapeutic agents triggered senescence in human umbilical vein endothelial cells (HUVECs).
- Etoposide was the most potent inducer of senescence, while methotrexate was the weakest.
- Increased levels of DNA damage markers and (ROS) were observed alongside .
- Mito-Q, a ROS scavenger, alleviated methotrexate-induced senescence but did not affect senescence caused by other agents.
- The p53 signaling pathway was identified as a key factor in chemotherapy-induced cellular senescence.
- The study suggests that targeting ROS may improve the safety of chemotherapy by protecting endothelial function.
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Key numbers
80%
Etoposide Induction Rate
Percentage of SA-β-gal-positive after etoposide treatment.
40%
Methotrexate Induction Rate
Percentage of SA-β-gal-positive after methotrexate treatment.