Circulation

The Oxidized Lipid PGPC Reduces New Blood Vessel Growth by Blocking Cell Cleanup Fusion Through NPC1-Triggered Changes in Syntaxin 17

Updated

Abstract

PGPC is a major phospholipid oxidation product found in atherosclerotic lesions.

  • Angiogenesis is critical for healing ischemic hearts affected by coronary artery disease.
  • The role of autophagy in angiogenesis suggests a potential link between these processes.
  • It is unknown if PGPC influences angiogenesis in ischemic hearts through the regulation of autophagy.

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