Oxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling.
Oxytocin production and receptor activity in lung small cell cancer cells may promote tumor growth through self-signaling
AI simplified
Abstract
Binding of a specific vasotocin showed a dissociation constant ranging from 0.025-0.089 nM across three small cell carcinoma of the lung cell lines.
- Oxytocin receptor expression and oxytocin synthesis were detected in three different small cell carcinoma of the lung cell lines (DMS79, H146, H345).
- Binding studies confirmed the presence of oxytocin and vasopressin receptors on these cell lines.
- Exogenous oxytocin exhibited a dose-dependent stimulation of cell growth in H345 cells, which was blocked by an oxytocin receptor antagonist.
- A decrease in cell proliferation was noted with the oxytocin receptor antagonist alone, indicating that tumor-derived oxytocin may promote growth.
- These findings suggest that oxytocin-mediated signaling plays a role in the growth and development of small cell carcinoma of the lung.
AI simplified