We can’t show the full text here under this license. Use the link below to read it at the source.
Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health
The children's gut virus community and its link to digestion, metabolism, and brain development
AI simplified
Abstract
The paediatric gut virome is the most abundant and genetically diverse biological entity in the intestine.
- The gut virome, which includes bacteriophages and various viruses, plays a crucial role in shaping the microbial community and immune development during early life.
- Early-life viral exposures may influence mucosal immune imprinting, epithelial barrier integrity, and immune tolerance within the first 1000 days of life.
- Dysbiosis of the virome is associated with several paediatric gastrointestinal disorders, including inflammatory bowel disease and celiac disease.
- The virome contributes to metabolic regulation and may affect the risk of type 1 diabetes and gut-brain communication, potentially influencing neurodevelopment.
- Mechanisms involving phage interactions with bacteria and immune responses are key to understanding the virome's role in maintaining gastrointestinal and systemic balance.
AI simplified