Pannexin 1 reduces liver fat buildup and insulin resistance by activating energy and cell-cleaning pathways
Updated
Abstract
Over 25% of the global population is affected by metabolic dysfunction-associated fatty liver disease (MASLD).
- Pannexin 1 (Panx1) may play a role in metabolic regulation related to liver health.
- The specific involvement of Panx1 in liver fat metabolism has not been previously studied.
- There is a hypothesis that Panx1 regulates the AMPK-autophagy axis, which could influence liver fat buildup and insulin sensitivity.
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Competing interests
Declarations. Approval of ethics and consent for participation: The animal study protocol was approved by the Animal Care and Use Committee (ACUC) of Shanghai General Hospital. The study adhered to the guidelines set by the committee. Consent for publication: All authors have agreed to publish this manuscript. Competing interests: The authors have declared that no competing interest exists.
PubMed