ASSOCIATION OF PARAOXONASE 1 L55M AND Q192R SINGLE-NUCLEOTIDE POLYMORPHISMS WITH AGE-RELATED MACULAR DEGENERATION

Published Mar 30, 2013Retina (Philadelphia, Pa.)

Links between two paraoxonase 1 gene variants and age-related macular degeneration

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Page updated Mar 29, 2026

Abstract

The PON1 MM and QQ genotypes were associated with a lower risk of age-related macular degeneration (AMD).

The frequency of the PON1 MM genotype was 4% in AMD patients compared to 13% in controls.
The frequency of the PON1 QQ genotype was 15% in AMD patients compared to 27% in controls.
Multivariate analysis adjusted for age, gender, and health factors showed MM genotype had an odds ratio of 0.24 for AMD risk.
The QQ genotype had an odds ratio of 0.46 for AMD risk after adjustment for confounding factors.

AI simplified

PURPOSE: To determine if paraoxonase 1 (PON1) gene polymorphisms have an effect on the risk of having age-related macular degeneration (AMD).

METHODS: The study population consisted of 142 patients who were diagnosed with either exudative or atrophic AMD and 138 sex- and age-matched controls without AMD. Genotyping of the PON1 L55M and Q192R single-nucleotide polymorphisms was performed using real-time polymerase chain reaction and commercially produced kits. A full ophthalmic evaluation was performed in each subject, and all subjects were screened for hypertension, diabetes, hypercholesterolemia, and smoking history.

RESULTS: The PON1 MM and QQ genotypes were less frequent in patients with AMD than in control subjects (MM: 4 vs. 13%, P = 0.015; QQ: 15 vs. 27%, P = 0.020). A multivariate logistic regression analysis was also conducted. After adjusting for age, gender, and the prevalence of smoking, hypertension, diabetes, and hypercholesterolemia, the MM and QQ genotypes (MM/QQ vs. LL + LM/QR + RR) were found to be associated with a decreased risk of AMD (MM: odds ratio = 0.24, P = 0.007, 95% confidence interval: 0.09-0.68; QQ: odds ratio = 0.46, P = 0.013, 95% confidence interval: 0.25-0.85).

CONCLUSION: The authors found that subjects with the PON1 MM and QQ genotypes had a lower risk of AMD.

Full Text

Full text is available at the source.

View full text ↗

ASSOCIATION OF PARAOXONASE 1 L55M AND Q192R SINGLE-NUCLEOTIDE POLYMORPHISMS WITH AGE-RELATED MACULAR DEGENERATION

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief