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High rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in Benin
High return of malaria parasites after preventive sulphadoxine-pyrimethamine treatment in pregnant women in Benin
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Abstract
The prevalence of pfdhfr/pfdhps quadruple mutants was consistently above 80% among 982 pregnant women in Benin.
- SP failed to clear existing parasitaemia in 48% of women infected at the scheduled treatment.
- The frequency of recrudescence reached 76% after the second dose of SP.
- Women with persistent parasitaemia had an increased prevalence of anaemia (P = 0.03).
- Highly mutated parasites did not include the two key mutations, pfdhfr 164 L or pfdhps 540E.
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