Long-Term Exposure to Particulate Air Pollution, Black Carbon, and Their Source Components in Relation to Ischemic Heart Disease and Stroke

Oct 31, 2019Environmental health perspectives

Long-term exposure to tiny air pollution particles, black carbon, and their sources linked to heart disease and stroke

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Abstract

5,166 incident ischemic heart disease (IHD) and 3,119 stroke cases were observed in 114,758 participants.

Long-term exposure to locally emitted black carbon (BC) from traffic exhaust is associated with a 4.0% higher risk of incident stroke per interquartile range increase.
Same-year levels of particulate matter from other sources, such as road wear and residential heating, were not consistently associated with stroke or IHD incidence.
Incident IHD was specifically linked to exposure from residential heating, while other particulate matter types did not show significant associations.
The overall low exposure levels in the study populations may have limited the detection of associations between particulate matter and cardiovascular incidents.

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BACKGROUND: Long-term exposure to particulate matter (PM) in ambient air has been associated with cardiovascular mortality, but few studies have considered incident disease in relation to PM from different sources.

OBJECTIVES: We aimed to study associations between long-term exposure to different types of PM and sources, and incident ischemic heart disease (IHD) and stroke in three Swedish cities.

METHODS: Based on detailed emission databases, monitoring data, and high-resolution dispersion models, we calculated source contributions to PM with aerodynamic diameter(), PM with aerodynamic diameter(), and black carbon (BC) from road wear, traffic exhaust, residential heating, and other sources in Gothenburg, Stockholm, and Umeå. Registry data for participants from four cohorts were used to obtain incidence of IHD and stroke for first hospitalization or death. We constructed time windows of exposure for same-year, 1- to 5-y, and 6- to 10-y averages preceding incidence from annual averages at residential addresses. Risk estimates were based on random effects meta-analyses of cohort-specific Cox proportional hazard models. ≤ 10μ m PM10 ≤ 2.5μ m PM2.5

RESULTS: We observed 5,166 and 3,119 incident IHD and stroke cases, respectively, in 114,758 participants. Overall, few consistent associations were observed between the different air pollution measures and IHD or stroke incidence. However, same-year levels of ambient locally emitted BC (range:) were associated with a 4.0% higher risk of incident stroke per interquartile range (IQR),[95% confidence interval (CI): 0.04, 7.8]. This association was primarily related to BC from traffic exhaust.(range:) and(range:) were not associated with stroke. Associations with incident IHD were observed only forexposure from residential heating. 0.01 4.6 - μ g m / 3 0.3 μ g m / 3PM10 4.4 52 - μ g m / 3PM2.5 2.9 22 - μ g m / 3PM2.5

DISCUSSION: Few consistent associations were observed between different particulate components and IHD or stroke. However, long-term residential exposure to locally emitted BC from traffic exhaust was associated with stroke incidence. The comparatively low exposure levels may have contributed to the paucity of associations. https://doi.org/10.1289/EHP4757.

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Long-Term Exposure to Particulate Air Pollution, Black Carbon, and Their Source Components in Relation to Ischemic Heart Disease and Stroke

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