Long-term exposure to particulate air pollution and incidence of Parkinson's disease: A nationwide population-based cohort study in South Korea

Apr 1, 2022Environmental research

Long-term exposure to air pollution particles and risk of Parkinson's disease in South Korea

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

During 8 years of follow-up, 0.8% of 313,355 participants developed Parkinson's disease.

A 1.08 hazard ratio indicates a potential association between a 3.3 μg/m increase in fine particulate matter exposure over the previous year and the incidence of Parkinson's disease.
In subgroup analyses, hazard ratios for fine particulate matter exposure were higher among older participants, males, those living in metropolitan areas, ibuprofen users, and individuals with comorbidities, ranging from 1.10 to 1.20.
The findings suggest that long-term exposure to fine particulate matter may contribute to the development of Parkinson's disease.

AI simplified

There has been increasing interest in the neurological impact of particulate matter (PM). However, its association with the incidence of Parkinson's disease (PD) remains unclear. We selected 313,355 participants satisfying inclusion criteria from the National Health Insurance Service-National Sample Cohort based on the nationwide population of South Korea, and followed them up from January 2007 through December 2015. Individual-level long-term PM exposure was assessed as the five time-varying average concentrations estimated for the previous 1, 2, 3, 4 and 5 years on each year (until censored or event occurred) at the district-level residential addresses of participants using a previously validated prediction model. Incident PD was defined as the first diagnosis accompanied by anti-PD medication prescription from 2007 through 2015. Time-varying Cox proportional hazards models were employed to estimate the hazard ratio (HR) of incident PD for long-term PM exposure, adjusting for individual- and area-level covariates. During the 8 years (2,745,389 person-years) of follow-up for a total of 313,355 participants (mean [range] age, 48.9 [19-87] years; 169,571 males [54.1%]), 2621 participants (0.8%) developed PD. The HR of incident PD per interquartile range (3.3 μg/m) increase in fine PM (PM) for the previous 1 year was 1.08 (95% confidence interval: 1.01-1.19). In subgroup-specific analyses, HRs for PMwere significant among older participants, males, participants living in metropolitan cities, ibuprofen users, and participants with comorbidities (HR: 1.10-1.20). Long-term exposure to PMmight play a role in PD development. 3 2.5 2.5 2.5

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Long-term exposure to particulate air pollution and incidence of Parkinson's disease: A nationwide population-based cohort study in South Korea

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief