Biochemical and biophysical research communicationsAug 22, 2026

Low levels of a key receptor weaken the brain's protective barrier and speed up cell aging in the memory area

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Aug 23, 2026

Abstract

Abnormalities in the PDGFR-β signaling pathway may be closely associated with neurodegenerative diseases.

PDGFR-β is a key marker of cerebrovascular pericytes and is important for regulating their function.
Maintaining the stability of the blood-brain barrier (BBB) is linked to proper PDGFR-β signaling.
Gene deficiency in PDGFR-β could lead to systemic changes in the hippocampal microenvironment.
These changes may impair neurogenesis and contribute to cellular aging.

Simplified

Platelet-Derived Growth Factor Receptor Beta (PDGFR-β), a key marker of cerebrovascular pericytes, plays a crucial role in regulating pericyte function and maintaining the stability of the blood-brain barrier (BBB). Recent studies suggest that abnormalities in the PDGFR-β signaling pathway may be closely associated with the onset and progression of neurodegenerative diseases. However, the causal relationship and specific mechanisms by which PDGFR-β gene deficiency directly leads to systemic pathological alterations in the hippocampal microenvironment, subsequently causing impaired neurogenesis and cellular senescence, remain unclear.

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Low levels of a key receptor weaken the brain's protective barrier and speed up cell aging in the memory area

Abstract

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