Expression ofPeriodGenes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker

Sep 22, 2001The Journal of neuroscience : the official journal of the Society for Neuroscience

Daily and steady patterns of Period gene activity in the brain’s biological clock center

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

The suprachiasmatic nucleus (SCN) contains two compartments that differentially regulate the expression of Period genes.

  • One SCN compartment exhibits endogenous rhythmicity in the expression of Per1, Per2, and Per3 genes.
  • The other SCN compartment does not show rhythmic mRNA expression but responds to light by inducing Per1 and Per2 expression.
  • This second compartment has high levels of nonrhythmic Per3 mRNA expression.
  • Differential regulation of clock genes in these compartments may contribute to functional differences within distinct SCN regions.

AI simplified

Full Text

Full text is available at the source.
View full text ↗

Related papers

Apr '03
Day length differently affects daily rhythm gene activity in the brain’s internal clock of Syrian hamsters
cited by 89 papers
comparative study
May '06
How the rat's internal day-night clock develops and adjusts to day length
top 30% journal
cited by 16 papers
research support, non-u.s. gov't
Nov '03
Daily patterns of PER2 protein in two parts of the rat’s biological clock: no change with light timing but disrupted by constant light
cited by 29 papers
research support, non-u.s. gov't
Nov '05
Development of how the rat’s internal clock in the brain adjusts to day length
top 20% journal
cited by 15 papers
research support, non-u.s. gov't
May '06
Body clock controls daily rhythms and light response in the brain but not in liver and muscle
top 20% journal
cited by 39 papers
journal article
Feb '03
Daily patterns and light effects on internal clock genes in the brain’s time-keeping center of a daytime-active mammal
cited by 100 papers
journal article
Aug '03
Unlike other signals, a single melatonin dose does not quickly change clock gene activity in the rat's internal clock center
cited by 74 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #35
Bacteria exposure resets your internal clock independently of immune responses
2 days ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
1 week ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
2 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
3 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
4 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
5 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
6 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
7 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
8 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief