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Efficacy and safety of perioperative melatonin for postoperative delirium in patients undergoing surgery: a systematic review and meta-analysis
Melatonin's safety and effectiveness for preventing confusion after surgery
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Abstract
In a review of 16 randomized controlled trials involving 1981 patients, the incidence of was significantly lower in the treatment group with a risk ratio of 0.57.
- Higher doses of melatonin resulted in a reduced incidence of postoperative delirium, with a risk ratio of 0.41 compared to the control group.
- Low-dose melatonin and the melatonin agonist ramelteon did not show a significant benefit in preventing postoperative delirium.
- Treatment with melatonin was particularly effective in reducing postoperative delirium in the early postoperative period, with a risk ratio of 0.35.
- Patients undergoing cardiopulmonary surgery also experienced a lower incidence of postoperative delirium when treated with melatonin, indicated by a risk ratio of 0.54.
- No severe adverse events were reported with perioperative melatonin or melatonin agonist treatment.
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Key numbers
0.57
Decrease in Incidence
incidence was 16.9% in the Mel-agonist group vs. 25.3% in the control group.
0.41
High-Dose Melatonin Effectiveness
Risk ratio for incidence in the high-dose melatonin group vs. control.