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Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health
Drugs that boost cell energy production by targeting key regulators PGC-1α, AMPK, and SIRT1
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Abstract
Various pharmacological agents activate mitochondrial biogenesis through different pathways.
- Agents such as resveratrol, curcumin, and metformin are associated with enhanced mitochondrial function.
- SIRT1 activators and AMPK agonists may improve mitochondrial health.
- Advancements in mitochondria-targeted drug delivery systems could enhance therapeutic effectiveness.
- Challenges in clinical translation arise from the complexity of mitochondrial regulation.
- Preclinical studies suggest potential for treating metabolic and neurodegenerative diseases.
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